From Wikipedia, the free encyclopedia
Succinate-semialdehyde dehydrogenase (acylating) (
EC
1.2.1.76 , succinyl-coA reductase , coenzyme-A-dependent succinate-semialdehyde dehydrogenase ) is an
enzyme with
systematic name succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating) .
[1]
[2]
[3] This enzyme
catalyses the following
chemical reaction
succinate semialdehyde + CoA + NADP+
⇌
{\displaystyle \rightleftharpoons }
succinyl-CoA + NADPH + H+
Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.
References
^ Söhling B, Gottschalk G (February 1993).
"Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri" . European Journal of Biochemistry . 212 (1): 121–7.
doi :
10.1111/j.1432-1033.1993.tb17641.x .
PMID
8444151 .
^ Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G (December 2006).
"Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp" (PDF) . Journal of Bacteriology . 188 (24): 8551–9.
doi :
10.1128/JB.00987-06 .
PMC
1698253 .
PMID
17041055 .
^ Berg IA, Kockelkorn D, Buckel W, Fuchs G (December 2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science . 318 (5857): 1782–6.
doi :
10.1126/science.1149976 .
PMID
18079405 .
External links
Activity Regulation Classification Kinetics Types