From Wikipedia, the free encyclopedia
Bacterial gene
PncA is a gene encoding
pyrazinamidase in
Mycobacterium species.
[1]
Pyrazinamidase converts the drug
pyrazinamide to the active form
pyrazinoic acid .
[2] There is a strong correlation between mutations in pncA and resistance of
M. tuberculosis to pyrazinamide.
[3]
See also
References
^ Scorpio A, Zhang Y (June 1996). "Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus". Nat. Med . 2 (6): 662–7.
doi :
10.1038/nm0696-662 .
PMID
8640557 .
S2CID
8579133 .
^ Whitfield, Michael G.; Soeters, Heidi M.; Warren, Robin M.; York, Talita; Sampson, Samantha L.; Streicher, Elizabeth M.; Helden, Paul D. van; Rie, Annelies van (2015-07-28).
"A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis" . PLOS ONE . 10 (7): e0133869.
Bibcode :
2015PLoSO..1033869W .
doi :
10.1371/journal.pone.0133869 .
ISSN
1932-6203 .
PMC
4517823 .
PMID
26218737 .
^ Juréen, Pontus; Werngren, Jim; Toro, Juan-Carlos; Hoffner, Sven (2016-12-15).
"Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis" . Antimicrobial Agents and Chemotherapy . 52 (5): 1852–1854.
doi :
10.1128/AAC.00110-08 .
ISSN
0066-4804 .
PMC
2346646 .
PMID
18316515 .