Polyuridylation, also called oligouridylation, is the addition of several uridine nucleotides to the 3' end of an RNA. Cytoplasmic poly(U) polymerases can add uridine nucleotides to both coding and non-coding RNAs. This addition may occur throughout a variety of RNA types including mRNAs, small RNAs, miRNAs, siRNAs, guide RNAs, or piRNAs. [1] Polyuridylation has been shown to play a role in gene regulation as an evolutionarily conserved process in eukaryotes. [2]
One group of RNAs that can be polyuridylated are histone mRNAs that lack a poly(A) tail. Polyuridylation of a histone mRNA promotes its degradation, involving the exosome. Other RNAs in Arabidopsis and mouse have been seen to be polyuridinylated after cleavage. [3]
References
- ^ Munoz-Tello P, Rajappa L, Coquille S, Thore S (15 April 2015). "Polyuridylation in Eukaryotes: A 3'-End Modification Regulating RNA Life". BioMed Research International. 2015: 968127. doi: 10.1155/2015/968127. PMC 4442281. PMID 26078976.
- ^ Rissland OS, Mikulasova A, Norbury CJ (May 2007). "Efficient RNA polyuridylation by noncanonical poly(A) polymerases". Molecular and Cellular Biology. 27 (10): 3612–3624. doi: 10.1128/MCB.02209-06. PMC 1899984. PMID 17353264.
- ^ Wilusz CJ, Wilusz J (January 2008). "New ways to meet your (3') end oligouridylation as a step on the path to destruction". Genes & Development. 22 (1): 1–7. doi: 10.1101/gad.1634508. PMC 2731568. PMID 18172159.
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