From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
U4/U6 small nuclear ribonucleoprotein Prp4 is a
protein that in humans is encoded by the PRPF4
gene .
[5]
[6]
[7]
The removal of
introns from nuclear pre-mRNAs occurs on complexes called
spliceosomes , which are made up of 4
small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by
OMIM
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000136875 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000066148 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Lauber J, Plessel G, Prehn S, Will CL, Fabrizio P, Groning K, Lane WS, Luhrmann R (Sep 1997).
"The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p" . RNA . 3 (8): 926–41.
PMC
1369537 .
PMID
9257651 .
^ Horowitz DS, Kobayashi R, Krainer AR (Dec 1997).
"A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs" . RNA . 3 (12): 1374–87.
PMC
1369579 .
PMID
9404889 .
^
a
b
"Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)" .
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Horowitz DS, Krainer AR (1997).
"A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor" . Genes Dev . 11 (1): 139–51.
doi :
10.1101/gad.11.1.139 .
PMID
9000057 .
Wang A, Forman-Kay J, Luo Y, et al. (1997).
"Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome" . Hum. Mol. Genet . 6 (12): 2117–26.
doi :
10.1093/hmg/6.12.2117 .
PMID
9328476 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Heng HH, Wang A, Hu J (1998). "Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33". Genomics . 48 (2): 273–5.
doi :
10.1006/geno.1997.5181 .
PMID
9521884 .
Kojima T, Zama T, Wada K, et al. (2001).
"Cloning of human PRP4 reveals interaction with Clk1" . J. Biol. Chem . 276 (34): 32247–56.
doi :
10.1074/jbc.M103790200 .
PMID
11418604 .
Gonzalez-Santos JM, Wang A, Jones J, et al. (2002).
"Central region of the human splicing factor Hprp3p interacts with Hprp4p" . J. Biol. Chem . 277 (26): 23764–72.
doi :
10.1074/jbc.M111461200 .
PMID
11971898 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Reidt U, Wahl MC, Fasshauer D, et al. (2003).
"Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide" (PDF) . J. Mol. Biol . 331 (1): 45–56.
doi :
10.1016/S0022-2836(03)00684-3 .
hdl :
11858/00-001M-0000-0012-F239-9 .
PMID
12875835 .
Ingelfinger D, Göthel SF, Marahiel MA, et al. (2004).
"Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH" . Nucleic Acids Res . 31 (16): 4791–6.
doi :
10.1093/nar/gkg660 .
PMC
169899 .
PMID
12907720 .
Stanĕk D, Neugebauer KM (2004).
"Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer" . J. Cell Biol . 166 (7): 1015–25.
doi :
10.1083/jcb.200405160 .
PMC
2172029 .
PMID
15452143 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83.
Bibcode :
2005Natur.433...77A .
doi :
10.1038/nature03207 .
PMID
15635413 .
S2CID
4344740 .
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–5.
Bibcode :
2005Sci...307.1621B .
doi :
10.1126/science.1105776 .
PMID
15761153 .
S2CID
39457788 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Liu S, Rauhut R, Vornlocher HP, Lührmann R (2006).
"The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP" . RNA . 12 (7): 1418–30.
doi :
10.1261/rna.55406 .
PMC
1484429 .
PMID
16723661 .
Huang B, Ahn YT, McPherson L, et al. (2007).
"Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription" . J. Immunol . 178 (11): 7081–7.
doi :
10.4049/jimmunol.178.11.7081 .
PMC
2674583 .
PMID
17513757 .