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Class of enzymes
Polyprenol reductase (
EC
1.3.1.94 , SRD5A3 (gene) , DFG10 (gene) ) is an
enzyme with
systematic name ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase .
[1]
[2] This enzyme
catalyses the following
chemical reaction
ditrans, polycis-dolichol + NADP+
⇌
{\displaystyle \rightleftharpoons }
ditrans, polycis-polyprenol + NADPH + H+
The reaction occurs in the reverse direction.
See also
References
^ Sagami H, Kurisaki A, Ogura K (May 1993). "Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver". The Journal of Biological Chemistry . 268 (14): 10109–13.
PMID
8486680 .
^ Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blümel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG (July 2010).
"SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder" . Cell . 142 (2): 203–17.
doi :
10.1016/j.cell.2010.06.001 .
PMC
2940322 .
PMID
20637498 .
External links
Activity Regulation Classification Kinetics Types