| Phenylacetone monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.92 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a phenylacetone monooxygenase ( EC 1.14.13.92) is an enzyme that catalyzes the chemical reaction
- phenylacetone + NADPH + H+ + O2 benzyl acetate + NADP+ + H2O
The 4 substrates of this enzyme are phenylacetone, NADPH, H+, and O2, whereas its 3 products are benzyl acetate, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is phenylacetone,NADPH:oxygen oxidoreductase. This enzyme is also called PAMO.
References
- Malito E, Alfieri A, Fraaije MW, Mattevi A (2004). "Crystal structure of a Baeyer–Villiger monooxygenase". Proc. Natl. Acad. Sci. U.S.A. 101 (36): 13157–62. doi: 10.1073/pnas.0404538101. PMC 516541. PMID 15328411.
- DB; Wu, J; Heuts, DP; Van Hellemond, EW; Spelberg, JH; Janssen, DB (2005). "Discovery of a thermostable Baeyer-Villiger monooxygenase by genome mining". Appl. Microbiol. Biotechnol. 66 (4): 393–400. doi: 10.1007/s00253-004-1749-5. PMID 15599520. S2CID 24375548.
