The parathyroid hormone family is a
family of structurally and functionally related
proteins.
Parathyroid hormone (PTH) is a polypeptidic hormone primarily involved in
calcium metabolism. The
parathyroid hormone-related protein (PTH-rP) is a related protein with predominantly paracrine function and possibly an endocrine role in lactation, as PTHrP has been found to be secreted by
mammary glands into the circulation and increase bone turnover.[1][2] PTH and PTH-rP bind to the same
G-protein coupled receptor.[3] The related protein
PTH-L has been found in
teleost fish, which also have two forms of PTH and PTHrP.[4] Three subfamilies can be identified: PTH, PTHrP and PTH-L.[5]
^Guerreiro PM, Renfro JL, Power DM, Canario AV (February 2007). "The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish". Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 (2): R679–96.
CiteSeerX10.1.1.319.8873.
doi:
10.1152/ajpregu.00480.2006.
PMID17023665.