From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 14 is a biologically active
protein that in humans is encoded by the FGF14
gene .
[5]
[6]
[7]
The protein encoded by this gene is a member of the
fibroblast growth factor (FGF) family. FGF family members possess broad
mitogenic and cell survival activities and are involved in a variety of biological processes, including
embryonic development, cell growth,
morphogenesis , tissue repair,
tumor growth, and invasion. A mutation in this gene is associated with
autosomal dominant
cerebellar ataxia .
Alternatively spliced transcript variants have been found for this gene.
[7]
FGF14 is mainly expressed in the
central nervous system and is associated with
neurodegenerative diseases such as
spinocerebellar ataxia (SCA27). FGF14 deficiency also impairs the maturation of cells in the
hippocampus , which is possibly related to the development of
schizophrenia .
[8]
Relationship with Alzheimer's disease
FGF14 levels are elevated in patients with
Alzheimer's disease . FGF14
messenger RNA was also found to be
upregulated in Alzheimer's patients, which suggests that it is involved in the pathogenesis of the disease, although the underlying mechanism is still unknown. Research is ongoing as to whether or not FGF14 could be used as a therapy against Alzheimer's disease as well as other neurodegenerative diseases, by promote neural proliferation and regulating the plasticity of the synapses.
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000102466 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000025551 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996).
"Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development" . Proc Natl Acad Sci U S A . 93 (18): 9850–7.
Bibcode :
1996PNAS...93.9850S .
doi :
10.1073/pnas.93.18.9850 .
PMC
38518 .
PMID
8790420 .
^ Wozniak DF, Xiao M, Xu L, Yamada KA, Ornitz DM (Mar 2007).
"Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14" . Neurobiol Dis . 26 (1): 14–26.
doi :
10.1016/j.nbd.2006.11.014 .
PMC
2267915 .
PMID
17236779 .
^
a
b
"Entrez Gene: FGF14 fibroblast growth factor 14" .
^ Wang, Lusheng; Jing, Rongrong; Wang, Xing; Wang, Baohui; Guo, Keke; Zhao, Jungang; Gao, Shuang; Xu, Nuo; Xuan, Xuan (June 2021) [11 June 2021].
"A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer's disease model" . Annals of Translational Medicine . 9 (12): 994.
doi :
10.21037/atm-21-2492 .
ISSN
2305-5839 .
PMC
8267273 .
PMID
34277794 .
Further reading
Wang Q, Bardgett ME, Wong M, et al. (2002).
"Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14" . Neuron . 35 (1): 25–38.
doi :
10.1016/S0896-6273(02)00744-4 .
PMID
12123606 .
Chumakov I, Blumenfeld M, Guerassimenko O, et al. (2002).
"Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia" . Proc. Natl. Acad. Sci. U.S.A . 99 (21): 13675–80.
Bibcode :
2002PNAS...9913675C .
doi :
10.1073/pnas.182412499 .
PMC
129739 .
PMID
12364586 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
van Swieten JC, Brusse E, de Graaf BM, et al. (2003).
"A Mutation in the Fibroblast Growth Factor 14 Gene Is Associated with Autosomal Dominant Cerebral Ataxia" . Am. J. Hum. Genet . 72 (1): 191–9.
doi :
10.1086/345488 .
PMC
378625 .
PMID
12489043 .
Dunham A, Matthews LH, Burton J, et al. (2004).
"The DNA sequence and analysis of human chromosome 13" . Nature . 428 (6982): 522–8.
Bibcode :
2004Natur.428..522D .
doi :
10.1038/nature02379 .
PMC
2665288 .
PMID
15057823 .
Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004).
"Functional phylogeny relates LET-756 to fibroblast growth factor 9" . J. Biol. Chem . 279 (38): 40146–52.
doi :
10.1074/jbc.M405795200 .
PMID
15199049 .
Stevanin G, Durr A, Dussert C, et al. (2005). "Mutations in the FGF14 gene are not a major cause of spinocerebellar ataxia in Caucasians". Neurology . 63 (5): 936.
doi :
10.1212/01.wnl.0000137020.30604.1e .
PMID
15365159 .
S2CID
35093587 .
Dalski A, Atici J, Kreuz FR, et al. (2005).
"Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias" . Eur. J. Hum. Genet . 13 (1): 118–20.
doi :
10.1038/sj.ejhg.5201286 .
PMID
15470364 .
Lou JY, Laezza F, Gerber BR, et al. (2006).
"Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels" . J. Physiol . 569 (Pt 1): 179–93.
doi :
10.1113/jphysiol.2005.097220 .
PMC
1464207 .
PMID
16166153 .
Brusse E, de Koning I, Maat-Kievit A, et al. (2006). "Spinocerebellar ataxia associated with a mutation in the fibroblast growth factor 14 gene (SCA27): A new phenotype". Mov. Disord . 21 (3): 396–401.
doi :
10.1002/mds.20708 .
PMID
16211615 .
S2CID
25438944 .
Zhao Y, Lim SW, Tan EK (2007). "Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor". Am. J. Med. Genet. B Neuropsychiatr. Genet . 144 (3): 395–6.
doi :
10.1002/ajmg.b.30472 .
PMID
17221845 .
S2CID
41536996 .
Angiopoietin
CNTF
EGF (ErbB)
FGF
FGFR1
FGFR2
Agonists:
Ersofermin
FGF (
1 ,
2 (bFGF) ,
3 ,
4 ,
5 ,
6 ,
7 (
KGF ),
8 ,
9 ,
10 (KGF2) ,
17 ,
18 ,
22 )
Palifermin
Repifermin
Selpercatinib
Sprifermin
Trafermin
FGFR3
FGFR4 Unsorted
HGF (c-Met)
IGF
LNGF (p75NTR )
PDGF
RET (GFL)
SCF (c-Kit)
TGFβ
Trk
TrkA
Negative allosteric modulators:
VM-902A
TrkB
Agonists:
3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
Amitriptyline
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-Acetylserotonin
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
R13
TDP6
TrkC
VEGF Others
Additional growth factors:
Adrenomedullin
Colony-stimulating factors (see
here instead)
Connective tissue growth factor (CTGF)
Ephrins (
A1 ,
A2 ,
A3 ,
A4 ,
A5 ,
B1 ,
B2 ,
B3 )
Erythropoietin (see
here instead)
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
Interleukins /
T-cell growth factors (see
here instead)
Leukemia inhibitory factor (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
Thrombopoietin (see
here instead)
Wnt signaling proteins
Additional growth factor receptor modulators:
Cerebrolysin (neurotrophin mixture)