Research has demonstrated that the Niementowski quinazoline synthesis could be employed for the creation of potential
EGFR-inhibiting molecules. Hensbergen et al.[4] have shown a synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring.
^ Williamson, T. A. (1957). "The chemistry of quinazoline". In Elderfield, R. C. (ed.). Heterocyclic Compounds. Vol. 6. New York:
John Wiley & Sons. pp. 324–376.
^ Cuny, Eckehard; Lichtenthaler, F. W.; Moser, Alfred (1980). "Benzologs of allopurinol: Synthesis of pyrazolo [4,3-g] and [3,4-f] quinazolinones". Tetrahedron Lett.21 (32): 3029–3032.
doi:
10.1016/S0040-4039(00)77398-9.