NRIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GPO, 2GPP, 4S14, 4S15
Identifiers
Aliases	NRIP1, RIP140, nuclear receptor interacting protein 1, CAKUT3
External IDs	OMIM: 602490; MGI: 1315213; HomoloGene: 2606; GeneCards: NRIP1; OMA: NRIP1 - orthologs
Gene location ( Human) Chr. Chromosome 21 (human) [1] Band 21q11.2-q21.1 Start 14,961,235 bp [1] End 15,065,936 bp [1]
Gene location ( Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 C3.1 Start 76,084,288 bp [2] End 76,170,715 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis jejunal mucosa retinal pigment epithelium tail of epididymis lactiferous duct trabecular bone Skeletal muscle tissue of biceps brachii superficial temporal artery human penis Top expressed in lacrimal gland medullary collecting duct left colon lobe of prostate human fetus seminal vesicula renal corpuscle parotid gland subcutaneous adipose tissue ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glucocorticoid receptor binding signaling receptor binding transcription coregulator activity retinoid X receptor binding histone deacetylase binding androgen receptor binding core promoter sequence-specific DNA binding retinoic acid receptor binding protein binding transcription corepressor activity transcription coactivator activity estrogen receptor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleolus histone deacetylase complex nuclear speck nucleus nucleoplasm Biological process rhythmic process transcription, DNA-templated ovulation regulation of transcription by RNA polymerase II lipid storage androgen receptor signaling pathway positive regulation of transcription, DNA-templated cellular response to estradiol stimulus regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II ovarian follicle rupture circadian regulation of gene expression negative regulation of transcription by RNA polymerase II circadian rhythm Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8204 268903 Ensembl ENSG00000180530 ENSMUSG00000048490 UniProt P48552 Q8CBD1 RefSeq (mRNA) NM_003489 NM_173440 NM_001358238 RefSeq (protein) NP_003480 NP_775616 NP_001345167 Location (UCSC) Chr 21: 14.96 – 15.07 Mb Chr 16: 76.08 – 76.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear receptor-interacting protein 1 (NRIP1) also known as receptor-interacting protein 140 (RIP140) is a protein that in humans is encoded by the NRIP1 gene. ^{[5] [6]}

Function

Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein is a key regulator which modulates transcriptional activity of a variety of transcription factors, including the estrogen receptor. ^[7]

RIP140 has an important role in regulating lipid and glucose metabolism, ^[8] and regulates gene expression in metabolic tissues including heart, ^[9] skeletal muscle, ^[10] and liver. ^[11] A major role for RIP140 in adipose tissue is to block the expression of genes involved in energy dissipation and mitochondrial uncoupling, including uncoupling protein 1 and carnitine palmitoyltransferase 1b. ^[12]

Estrogen-related receptor alpha (ERRa) can activate RIP140 during adipogenesis, by means of directly binding to an estrogen receptor element/ERR element and indirectly through Sp1 binding to the proximal promoter. ^[13]

RIP140 suppresses the expression of mitochondrial proteins succinate dehydrogenase complex b and CoxVb and acts as a negative regulator of glucose uptake in mice. ^[14]

Knockout studies

Knockout mice that completely lack the RIP140 molecule are lean and stay lean, even on a rich diet. ^[15]

Knockout mice (females) are also infertile because they fail to ovulate. ^[16] Failure of ovulation in these mice is caused by lack of cumulus expansion and altered expression of various genes, including amphiregulin, in ovarian follicles. ^{[17] [18]}

Clinical significance

RIP140 is part of the chain by which tumors can cause cachexia. ^{[19] [20]}

Levels of RIP140 expression in various tissues varies during aging in mice, suggesting changes in metabolic function. ^[21] RIP140 is implicated in certain human disease processes. In morbid obesity, RIP140 levels are down-regulated in visceral adipose tissue. ^[22] In breast cancer, RIP140 is involved in regulation of E2F1, an oncogene which discriminates between luminal and basal types of tumours. RIP140 has an influence upon cancer phenotype and prognosis. ^[23] In addition, RIP140 has a role in inflammation, since it acts as a coactivator for NFkappaB/ RelA-dependent cytokine gene expression. Lack of RIP140 leads to an inhibition of proinflammatory pathways in macrophages. ^[24]

Interactions

NRIP1 has been shown to interact with:

See also

• Transcription coregulator

References

Further reading

External links

• NRIP1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C258
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Nuclear receptor-interacting protein 1 (NRIP1)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.