| Molybdopterin synthase sulfurtransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.1.11 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Molybdopterin synthase sulfurtransferase ( EC 2.8.1.11, adenylyltransferase and sulfurtransferase MOCS3, Cnx5 (gene), molybdopterin synthase sulfurylase) is an enzyme with systematic name persulfurated L-cysteine desulfurase:(molybdopterin-synthase sulfur-carrier protein)-Gly-Gly sulfurtransferase. [1] [2] [3] [4] This enzyme catalyses the following chemical reaction
- [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + cysteine desulfurase
The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of molybdopterin synthase.
References
- ^ Matthies A, Nimtz M, Leimkühler S (May 2005). "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry". Biochemistry. 44 (21): 7912–20. doi: 10.1021/bi0503448. PMID 15910006.
- ^ Leimkühler S, Rajagopalan KV (June 2001). "A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli". The Journal of Biological Chemistry. 276 (25): 22024–31. doi: 10.1074/jbc.M102072200. PMID 11290749.
- ^ Hänzelmann P, Dahl JU, Kuper J, Urban A, Müller-Theissen U, Leimkühler S, Schindelin H (December 2009). "Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains". Protein Science. 18 (12): 2480–91. doi: 10.1002/pro.260. PMC 2821267. PMID 19798741.
- ^ Dahl JU, Urban A, Bolte A, Sriyabhaya P, Donahue JL, Nimtz M, Larson TJ, Leimkühler S (October 2011). "The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli". The Journal of Biological Chemistry. 286 (41): 35801–12. doi: 10.1074/jbc.M111.282368. PMC 3195606. PMID 21856748.
External links
- Molybdopterin+synthase+sulfurtransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
