The miR-24 microRNA precursor is a small
non-coding RNA molecule that regulates gene expression.
microRNAs are transcribed as ~70
nucleotide precursors and subsequently processed by the
Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. miR-24 is conserved in various species, and is clustered with miR-23 and miR-27, on human chromosome 9 and 19.[1] Recently, miR-24 has been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc in hematopoietic differentiation [2] and also to promote keratinocyte differentiation by repressing actin-cytoskeleton regulators
PAK4,
Tsk5 and
ArhGAP19.[3]
Targets of miR-24
Lal et al. suggested that miR-24 suppresses the tumor suppressor
p16(INK4a).[1]
Lal et al. reported that mi-24 inhibits cell proliferation by targeting E2F2, MYC via binding to "seedless" 3'UTR microRNA recognition elements.[2]
Amelio I. et al. suggest that miR-24 regulates keratinocyte differentiation, controlling actin-cytoskeleton dynamics via
PAK4,
Tsk5 and
ArhGAP19 repression.[3]
Wang et al. have shown that miR-24 reduces the mRNA and protein levels of human
ALK4 by targeting the 3'-untranslated region of mRNA.[4]
Mishra et al. suggest that miR-24 targets the
DHFR gene.[5]
miR-24-1, also known as miR-189, targets
SLITRK1.[6][7]