miR-101 microRNA precursor is a small
non-coding RNA that regulates
gene expression. Expression of miR-101 has been validated in both human (
MI0000103,
MI0000739)[1] and mouse (
MI0000148).[2] This
microRNA appears to be specific to the
vertebrates and has now been predicted or confirmed in a wide range of vertebrate species (
MIPF0000046). The precursor microRNA is a
stem-loop structure of about 70
nucleotides in length that is processed by the
Dicer enzyme to form the 21-24 nucleotide mature microRNA. In this case the mature sequence is excised from the 3' arm of the
hairpin.
Survival analysis shows that hsa-miR-101 is associated with survival in multiple breast cancer datasets.[3]
^Lánczky A, Nagy Á, Bottai G, Munkácsy G, Szabó A, Santarpia L, Győrffy B (December 2016). "miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients". Breast Cancer Research and Treatment. 160 (3): 439–446.
doi:
10.1007/s10549-016-4013-7.
PMID27744485.
S2CID11165696.