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In enzymology, a methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase ( EC 2.1.1.90) is an enzyme that catalyzes the chemical reaction

methanol + 5-hydroxybenzimidazolylcobamide ${\displaystyle \rightleftharpoons }$ Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H₂O

Thus, the two substrates of this enzyme are methanol and 5-hydroxybenzimidazolylcobamide, whereas its two products are Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide and H₂O.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase. Other names in common use include methanol cobalamin methyltransferase, methanol:5-hydroxybenzimidazolylcobamide methyltransferase, and MT 1.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I2X.

References

Further reading