From Wikipedia, the free encyclopedia
Malonyl CoA reductase (malonate semialdehyde-forming) (
EC
1.2.1.75 , NADP-dependent malonyl CoA reductase , malonyl CoA reductase (NADP) ) is an
enzyme with
systematic name malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming) .
[1]
[2]
[3]
[4] This enzyme
catalyse the following
chemical reaction
malonate semialdehyde + CoA + NADP+
⇌
{\displaystyle \rightleftharpoons }
malonyl-CoA + NADPH + H+
Requires Mg2+ . Catalyses the reduction of malonyl-CoA to malonate semialdehyde.
References
^ Strauss G, Fuchs G (August 1993).
"Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle" . European Journal of Biochemistry . 215 (3): 633–43.
doi :
10.1111/j.1432-1033.1993.tb18074.x .
PMID
8354269 .
^ Berg IA, Kockelkorn D, Buckel W, Fuchs G (December 2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science . 318 (5857): 1782–6.
doi :
10.1126/science.1149976 .
PMID
18079405 .
^ Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G (December 2006).
"Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp" (PDF) . Journal of Bacteriology . 188 (24): 8551–9.
doi :
10.1128/JB.00987-06 .
PMC
1698253 .
PMID
17041055 .
^ Hügler M, Menendez C, Schägger H, Fuchs G (May 2002).
"Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation" . Journal of Bacteriology . 184 (9): 2404–10.
doi :
10.1128/jb.184.9.2404-2410.2002 .
PMC
134993 .
PMID
11948153 .
External links
Activity Regulation Classification Kinetics Types