From Wikipedia, the free encyclopedia
In
enzymology , a magnesium protoporphyrin IX methyltransferase (
EC
2.1.1.11 ) is an
enzyme that
catalyzes the
chemical reaction
S-adenosyl-L-methionine + magnesium protoporphyrin IX
⇌
{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + magnesium protoporphyrin IX 13-methyl ester
The two
substrates of this enzyme are
S-adenosyl methionine and
magnesium protoporphyrin IX ; its two
products are
S-adenosylhomocysteine and
magnesium protoporphyrin IX 13-methyl ester .
This enzyme belongs to the family of
transferases , specifically those transferring one-carbon group methyltransferases. The
systematic name of this enzyme class is S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase . This enzyme is part of the
biosynthetic pathway to
chlorophylls .
[1]
[2]
See also
References
GIBSON KD, NEUBERGER A, TAIT GH (1963).
"STUDIES ON THE BIOSYNTHESIS OF PORPHYRIN AND BACTERIOCHLOROPHYLL BY RHODOPSEUDOMONAS SPHEROIDES. 4. S-ADENOSYLMETHIONINEMAGNESIUM PROTOPORPHYRIN METHYLTRANSFERASE" . Biochem. J . 88 : 325–34.
PMC
1202116 .
PMID
14063871 .
Shepherd M, Reid JD, Hunter CN (2003).
"Purification and kinetic characterization of the magnesium protoporphyrin IX methyltransferase from Synechocystis PCC6803" . Biochem. J . 371 (Pt 2): 351–60.
doi :
10.1042/BJ20021394 .
PMC
1223276 .
PMID
12489983 .
Bollivar DW, Jiang ZY, Bauer CE, Beale SI (1994).
"Heterologous expression of the bchM gene product from Rhodobacter capsulatus and demonstration that it encodes S-adenosyl-L-methionine:Mg-protoporphyrin IX methyltransferase" . J. Bacteriol . 176 (17): 5290–6.
PMC
196713 .
PMID
8071204 .
Gibson LC, Hunter CN (1994). "The bacteriochlorophyll biosynthesis gene, bchM, of Rhodobacter sphaeroides encodes S-adenosyl-L-methionine: Mg protoporphyrin IX methyltransferase". FEBS Lett . 352 (2): 127–30.
doi :
10.1016/0014-5793(94)00934-1 .
PMID
7925960 .
Ebbon JG, Tait GH (1969).
"Studies on S-adenosylmethionine-magnesium protoporphyrin methyltransferase in Euglena gracilis strain Z" . Biochem. J . 111 (4): 573–82.
PMC
1187578 .
PMID
5774480 .
Activity Regulation Classification Kinetics Types