Long-chain acyl-CoA dehydrogenase (
EC1.3.8.8, palmitoyl-CoA dehydrogenase, palmitoyl-coenzyme A dehydrogenase, long-chain acyl-coenzyme A dehydrogenase, long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase, ACADL (gene).) is an
enzyme with
systematic namelong-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase.[1][2][3][4][5] This enzyme
catalyses the following
chemical reaction
a long-chain
acyl-CoA + electron-transfer
flavoprotein a long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
This enzyme contains FAD as
prosthetic group and participates in
fatty acid metabolism and
PPAR signaling pathway.[6] Mitochondrial mutations in this enzyme may be associated with some forms of dilated cardiomyopathy.
References
^Crane FL, Hauge JG, Beinert H (June 1955). "Flavoproteins involved in the first oxidative step of the fatty acid cycle". Biochimica et Biophysica Acta. 17 (2): 292–4.
doi:
10.1016/0006-3002(55)90374-7.
PMID13239683.
^Djordjevic S, Dong Y, Paschke R, Frerman FE, Strauss AW, Kim JJ (April 1994). "Identification of the catalytic base in long chain acyl-CoA dehydrogenase". Biochemistry. 33 (14): 4258–64.
doi:
10.1021/bi00180a021.
PMID8155643.