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Enzyme
Homospermidine synthase (
EC
2.5.1.44 ) is an
enzyme with
systematic name putrescine:putrescine 4-aminobutyltransferase (ammonia-forming) .
[1]
[2]
[3]
[4]
[5]
[6] This enzyme
catalyses the following
chemical reaction
(1) 2
putrescine
⇌
{\displaystyle \rightleftharpoons }
sym-homospermidine + NH3 + H+
(2) putrescine +
spermidine
⇌
{\displaystyle \rightleftharpoons }
sym-homospermidine + propane-1,3-diamine
The reaction of this enzyme occurs in three steps.
References
^ Tait GH (February 1979). "The formation of homospermidine by an enzyme from Rhodopseudomonas viridis [proceedings]". Biochemical Society Transactions . 7 (1): 199–201.
doi :
10.1042/bst0070199 .
PMID
437275 .
^ Böttcher F, Ober D, Hartmann T (1994).
"Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation" . Can. J. Chem . 72 : 80–85.
doi :
10.1139/v94-013 .
^ Yamamoto S, Nagata S, Kusaba K (July 1993). "Purification and characterization of homospermidine synthase in Acinetobacter tartarogenes ATCC 31105". Journal of Biochemistry . 114 (1): 45–9.
doi :
10.1093/oxfordjournals.jbchem.a124137 .
PMID
8407874 .
^ Srivenugopal KS, Adiga PR (August 1980).
"Enzymic synthesis of sym-homospermidine in Lathyrus sativus (grass pea) seedlings" . The Biochemical Journal . 190 (2): 461–4.
doi :
10.1042/bj1900461 .
PMC
1162113 .
PMID
7470060 .
^ Ober D, Tholl D, Martin W, Hartmann T (1996).
"Homospermidine synthase of Rhodopseudomonas viridis : Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli " . J. Gen. Appl. Microbiol . 42 (5): 411–419.
doi :
10.2323/jgam.42.411 .
^ Ober D, Hartmann T (December 1999).
"Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase" . Proceedings of the National Academy of Sciences of the United States of America . 96 (26): 14777–82.
Bibcode :
1999PNAS...9614777O .
doi :
10.1073/pnas.96.26.14777 .
PMC
24724 .
PMID
10611289 .
External links
Activity Regulation Classification Kinetics Types