From Wikipedia, the free encyclopedia
HIV-2 protease or retropepsin (
EC
3.4.23.47) is an
enzyme.
[1]
[2] This enzyme
catalyses the following
chemical reaction
-
Endopeptidase for which the P1 residue is preferably
hydrophobic
This enzyme belongs to the peptidase family A2.
References
-
^ Tözsér J, Bláha I, Copeland TD, Wondrak EM, Oroszlan S (April 1991).
"Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins". FEBS Letters. 281 (1–2): 77–80.
doi:
10.1016/0014-5793(91)80362-7.
PMID
2015912.
-
^ Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC (October 1994).
"Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases". The Journal of Biological Chemistry. 269 (42): 26344–8.
doi:
10.1016/S0021-9258(18)47199-2.
PMID
7929352.
External links
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