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Class of enzymes
Glycosyltransferase DesVII (
EC
2.4.1.277 , DesVII ) is an
enzyme with
systematic name dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:10-deoxymethynolide 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase .
[1]
[2]
[3] This enzyme
catalyses the following
chemical reaction
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose +
10-deoxymethynolide
⇌
{\displaystyle \rightleftharpoons }
dTDP + 10-deoxymethymycin
DesVII is the glycosyltransferase responsible for the attachment of TDP-D-desosamine to
macrolactones of varied ring sizes.
References
^ Borisova SA, Liu HW (September 2010).
"Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway" . Biochemistry . 49 (37): 8071–84.
doi :
10.1021/bi1007657 .
PMC
2939310 .
PMID
20695498 .
^ Borisova SA, Kim HJ, Pu X, Liu HW (July 2008).
"Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications" . ChemBioChem . 9 (10): 1554–8.
doi :
10.1002/cbic.200800155 .
PMC
4400176 .
PMID
18548476 .
^ Hong JS, Park SJ, Parajuli N, Park SR, Koh HS, Jung WS, Choi CY, Yoon YJ (January 2007). "Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation". Gene . 386 (1–2): 123–30.
doi :
10.1016/j.gene.2006.08.021 .
PMID
17049185 .
External links
Activity Regulation Classification Kinetics Types