From Wikipedia, the free encyclopedia
Protein family
Gingipains are a family of
proteases secreted by
Porphyromonas gingivalis. Among other functions, it works to degrade
cytokines, thereby
downregulating the host response in the form of reduced
inflammation.
[1] Gingipain has been studied for its potential role in the development of
Alzheimer's disease.
[2]
[3]
See also
References
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^ Stathopoulou, PG. Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. J Clin Perio 2010;37:24–29
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^
Dominy, S.S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C. and Holsinger, L.J., 2019. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Science Advances, 5(1), p.eaau3333.
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^
New Scientist 29 January 2019
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