5,6-dimethylbenzimidazole synthase | |||||||||
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Identifiers | |||||||||
EC no. | 1.14.99.40 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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5,6-dimethylbenzimidazole synthase ( EC 1.14.99.40, BluB) is an enzyme with systematic name FMNH2 oxidoreductase (5,6-dimethylbenzimidazole forming). [1] [2] [3] This enzyme catalyses the following chemical reaction
The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in bacteria.