The enzyme is inhibited by the antibiotic
fosfomycin, which covalently modifies an active site
cysteine residue.[3]
This enzyme belongs to the family of
transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The
systematic name of this enzyme class is phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase.[4] This enzyme participates in
amino sugars metabolism and
glycan biosynthesis.
^Other names in common use include MurA transferase, UDP-N-acetylglucosamine 1-carboxyvinyl-transferase, UDP-N-acetylglucosamine enoylpyruvyltransferase, enoylpyruvate transferase, phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase, phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase, phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase, phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase, phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase, pyruvate-UDP-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetyl-glucosamine transferase, and pyruvic-uridine diphospho-N-acetylglucosaminyltransferase.
Literature
Gunetileke KG, Anwar RA (1968). "Biosynthesis of uridine diphospho-N-acetylmuramic acid. II Purification and properties of pyruvate-uridine diphospho-N-acetylglucosamine transferase and characterization of uridine diphospho-N-acetylenopyruvylglucosamine". J. Biol. Chem. 243 (21): 5770–8.
PMID5699062.
Zemell RI, Anwar RA (1975). "Pyruvate-uridine diphospho-N-acetylglucosamine transferase Purification to homogeneity and feedback inhibition". J. Biol. Chem. 250 (8): 3185–92.
PMID1123336.
van Heijenoort J (2001). "Recent advances in the formation of the bacterial peptidoglycan monomer unit". Nat. Prod. Rep. 18 (5): 503–19.
doi:
10.1039/a804532a.
PMID11699883.