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In enzymology, a diferric-transferrin reductase ( EC 1.16.1.2) is an enzyme that catalyzes the chemical reaction

transferrin[Fe(II)]2 + NAD⁺ + H⁺ ${\displaystyle \rightleftharpoons }$ transferrin[Fe(III)]2 + NADH

The 3 substrates of this enzyme are [[transferrin[Fe(II)]2]], NAD⁺, and H⁺, whereas its two products are [[transferrin[Fe(III)]2]] and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is transferrin[Fe(II)]2:NAD+ oxidoreductase. Other names in common use include diferric transferrin reductase, NADH diferric transferrin reductase, and transferrin reductase. This enzyme participates in porphyrin and chlorophyll metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1L5T.

References

• Low H, Sun IL, Navas P, Grebing C, Crane FL, Morre DJ (1986). "Transplasmalemma electron transport from cells is part of a diferric transferrin reductase system". Biochem. Biophys. Res. Commun. 139 (3): 1117–23. doi: 10.1016/S0006-291X(86)80293-5. PMID  3767994.