From Wikipedia, the free encyclopedia
Enzyme
Dermatan 4-sulfotransferase (
EC
2.8.2.35 , dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase , dermatan-4-sulfotransferase-1 , dermatan-4-sulfotransferase 1 , D4ST-1 , dermatan N-acetylgalactosamine 4-O-sulfotransferase , CHST14 protein ,
CHST14 ) is an
enzyme with
systematic name 3'-phospho-5'-adenylyl sulfate:(dermatan)-N-acetyl-D-galactosamine 4-sulfotransferase .
[1]
[2]
[3]
[4] This enzyme
catalyses the following
chemical reaction
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine
⇌
{\displaystyle \rightleftharpoons }
adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine
The
sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of
dermatan .
References
^ Evers MR, Xia G, Kang HG, Schachner M, Baenziger JU (September 2001).
"Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase" . The Journal of Biological Chemistry . 276 (39): 36344–53.
doi :
10.1074/jbc.M105848200 .
PMID
11470797 .
^ Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K (September 2003).
"Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis" . The Journal of Biological Chemistry . 278 (38): 36115–27.
doi :
10.1074/jbc.M306044200 .
PMID
12847091 .
^ Pacheco B, Maccarana M, Malmström A (November 2009).
"Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate" . Glycobiology . 19 (11): 1197–203.
doi :
10.1093/glycob/cwp110 .
PMID
19661164 .
^ Mitsunaga C, Mikami T, Mizumoto S, Fukuda J, Sugahara K (July 2006).
"Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases" . The Journal of Biological Chemistry . 281 (28): 18942–52.
doi :
10.1074/jbc.M510870200 .
PMID
16702220 .
External links
Activity Regulation Classification Kinetics Types