Delta8-fatty-acid desaturase (
EC1.14.19.4, Delta8-sphingolipid desaturase, EFD1, BoDES8, SLD, Delta8 fatty acid desaturase, Delta8-desaturase) is an
enzyme with
systematic namephytosphinganine,hydrogen donor:oxygen Delta8-oxidoreductase.[1][2][3][4] This enzyme
catalyses the following
chemical reaction
This enzyme, which has been found mainly in
plants, introduces a double bond at Delta8 of C18 and C20
fatty acids.
References
^Wallis JG, Browse J (May 1999). "The Delta8-desaturase of Euglena gracilis: an alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids". Archives of Biochemistry and Biophysics. 365 (2): 307–16.
doi:
10.1006/abbi.1999.1167.
PMID10328826.
^Sperling P, Libisch B, Zähringer U, Napier JA, Heinz E (April 2001). "Functional identification of a delta8-sphingolipid desaturase from Borago officinalis". Archives of Biochemistry and Biophysics. 388 (2): 293–8.
doi:
10.1006/abbi.2001.2308.
PMID11368168.
^Takakuwa N, Kinoshita M, Oda Y, Ohnishi M (December 2002). "Isolation and characterization of the genes encoding delta(8)-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis". Current Microbiology. 45 (6): 459–61.
doi:
10.1007/s00284-002-3860-0.
PMID12402089.
S2CID25735503.
^Beckmann C, Rattke J, Oldham NJ, Sperling P, Heinz E, Boland W (July 2002). "Characterization of a Delta8-sphingolipid desaturase from higher plants: a stereochemical and mechanistic study on the origin of E,Z isomers". Angewandte Chemie. 41 (13): 2298–300.
doi:
10.1002/1521-3773(20020703)41:13<2298::AID-ANIE2298>3.0.CO;2-G.
PMID12203571.