From Wikipedia, the free encyclopedia
Cobalt-precorrin-5B (C1 )-methyltransferase (
EC
2.1.1.195 ), cobalt-precorrin-6A synthase , CbiD (gene) ) is an
enzyme with
systematic name S-adenosyl-L-methionine:cobalt-precorrin-5B (C1 )-methyltransferase .
[1]
[2] This enzyme
catalyses the following
chemical reaction
cobalt-precorrin-5B +
S-adenosyl-L-methionine
⇌
{\displaystyle \rightleftharpoons }
cobalt-precorrin-6A +
S-adenosyl-L-homocysteine
This enzyme catalyses the C-1
methylation of cobalt-precorrin-5B in the anaerobic pathway
[3] of
adenosylcobalamin biosynthesis in
bacteria such as
Salmonella typhimurium ,
Bacillus megaterium , and
Propionibacterium freudenreichii subsp. shermanii .
See also
References
^ Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ (December 2000).
"The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway" . The Journal of Biological Chemistry . 275 (51): 40316–23.
doi :
10.1074/jbc.M007146200 .
PMID
11007789 .
^ Roessner CA, Williams HJ, Scott AI (April 2005).
"Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin" . The Journal of Biological Chemistry . 280 (17): 16748–53.
doi :
10.1074/jbc.M501805200 .
PMID
15741157 .
^ R. Caspi (2013-09-25).
"Pathway: adenosylcobalamin biosynthesis I (anaerobic)" . MetaCyc Metabolic Pathway Database. Retrieved 2020-04-24 .
External links
Activity Regulation Classification Kinetics Types