From Wikipedia, the free encyclopedia
Carboxynorspermidine synthase
Identifiers
EC no. 1.5.1.43
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

Carboxynorspermidine synthase ( EC 1.5.1.43, carboxynorspermidine dehydrogenase, carboxyspermidine dehydrogenase, CASDH, CANSDH) is an enzyme with systematic name carboxynorspermidine:NADP+ oxidoreductase. [1] [2] [3] This enzyme catalyses the following chemical reactions

(1) carboxynorspermidine + H2O + NADP+ L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+
(2) carboxyspermidine + H2O + NADP+ L-aspartate 4-semialdehyde + putrescine + NADPH + H+

The reaction takes place in the opposite direction.

References

  1. ^ Nakao H, Shinoda S, Yamamoto S (July 1991). "Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus". Journal of General Microbiology. 137 (7): 1737–42. doi: 10.1099/00221287-137-7-1737. PMID  1955861.
  2. ^ Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ (April 2009). "An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae". The Journal of Biological Chemistry. 284 (15): 9899–907. doi: 10.1074/jbc.M900110200. PMC  2665113. PMID  19196710.
  3. ^ Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ (December 2011). "Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota". The Journal of Biological Chemistry. 286 (50): 43301–12. doi: 10.1074/jbc.M111.307835. PMC  3234850. PMID  22025614.

External links