From Wikipedia, the free encyclopedia
Carboxynorspermidine synthase (
EC
1.5.1.43, carboxynorspermidine dehydrogenase, carboxyspermidine dehydrogenase, CASDH, CANSDH) is an
enzyme with
systematic name carboxynorspermidine:NADP+ oxidoreductase.
[1]
[2]
[3] This enzyme
catalyses the following
chemical reactions
- (1)
carboxynorspermidine + H2O + NADP+
L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+
- (2)
carboxyspermidine + H2O + NADP+
L-aspartate 4-semialdehyde +
putrescine + NADPH + H+
The reaction takes place in the opposite direction.
References
-
^ Nakao H, Shinoda S, Yamamoto S (July 1991).
"Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus". Journal of General Microbiology. 137 (7): 1737–42.
doi:
10.1099/00221287-137-7-1737.
PMID
1955861.
-
^ Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ (April 2009).
"An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae". The Journal of Biological Chemistry. 284 (15): 9899–907.
doi:
10.1074/jbc.M900110200.
PMC
2665113.
PMID
19196710.
-
^ Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ (December 2011).
"Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota". The Journal of Biological Chemistry. 286 (50): 43301–12.
doi:
10.1074/jbc.M111.307835.
PMC
3234850.
PMID
22025614.
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