From Wikipedia, the free encyclopedia
Enzyme
Carbazole 1,9a-dioxygenase (
EC
1.14.12.22, CARDO) is an
enzyme with
systematic name 9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3-hydroxylating).
[1]
[2] This enzyme
catalyses the following
chemical reaction
-
9H-carbazole + NAD(P)H + H+ + O2
2'-aminobiphenyl-2,3-diol + NAD(P)+
Carbazole 1,9a-dioxygenase catalyses the first reaction in the pathway of
carbazole degradation.
References
-
^ Nam JW, Nojiri H, Noguchi H, Uchimura H, Yoshida T, Habe H, Yamane H, Omori T (December 2002).
"Purification and characterization of carbazole 1,9a-dioxygenase, a three-component dioxygenase system of Pseudomonas resinovorans strain CA10". Applied and Environmental Microbiology. 68 (12): 5882–90.
Bibcode:
2002ApEnM..68.5882N.
doi:
10.1128/aem.68.12.5882-5890.2002.
PMC
134387.
PMID
12450807.
-
^ Gai Z, Wang X, Liu X, Tai C, Tang H, He X, Wu G, Deng Z, Xu P (April 2010).
"The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5". PLOS ONE. 5 (4): e10018.
Bibcode:
2010PLoSO...510018G.
doi:
10.1371/journal.pone.0010018.
PMC
2848856.
PMID
20368802.
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