From Wikipedia, the free encyclopedia
CP-154,526
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Names
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Preferred IUPAC name
N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[3,2-e]pyrimidin-4-amine
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Identifiers
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ChEMBL
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ChemSpider
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UNII
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InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 NKey: FHQYJZCJRZHINA-UHFFFAOYSA-N NInChI=1/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 Key: FHQYJZCJRZHINA-UHFFFAOYAW
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CCCCN(CC)C1=NC(=NC2=C1C(=CN2C3=C(C=C(C=C3C)C)C)C)C
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Properties
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C23H32N4
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Molar mass
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364.52698
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
CP-154,526 is a potent and selective
antagonist of the
corticotropin releasing hormone receptor 1 developed by
Pfizer.
[1]
CP-154,526 is under investigation for the potential treatment of
alcoholism.
[2]
[3]
See also
References
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^ Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley FD, Winston EN, Chen YL, Heym J (September 1996).
"CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (19): 10477–82.
Bibcode:
1996PNAS...9310477S.
doi:
10.1073/pnas.93.19.10477.
PMC
38410.
PMID
8816826.
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^
"Drug Has Potential To Prevent Alcoholics From Relapsing". Science News. ScienceDaily. 2008-08-02. Retrieved 2008-08-09.
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^ Pastor R, McKinnon CS, Scibelli AC, Burkhart-Kasch S, Reed C, Ryabinin AE, Coste SC, Stenzel-Poore MP, Phillips TJ (July 2008).
"Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism". Proceedings of the National Academy of Sciences of the United States of America. 105 (26): 9070–5.
Bibcode:
2008PNAS..105.9070P.
doi:
10.1073/pnas.0710181105.
PMC
2449366.
PMID
18591672.
Further reading
- Seymour PA, Schmidt AW, Schulz DW (2006).
"The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review". CNS Drug Reviews. 9 (1): 57–96.
doi:
10.1111/j.1527-3458.2003.tb00244.x.
PMC
6741649.
PMID
12595912.
- Navarro-Zaragoza J, Núñez C, Laorden ML, Milanés MV (May 2010). "Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal". Molecular Pharmacology. 77 (5): 864–73.
doi:
10.1124/mol.109.062463.
PMID
20159948.
S2CID
18588298.
- Kobayashi T, Kiyokawa Y, Takeuchi Y, Mori Y (September 2011).
"Pretreatment with CP-154526 blocks the modifying effects of alarm pheromone on components of sexual behavior in male, but not in female, rats". Chemical Senses. 36 (7): 623–32.
doi:
10.1093/chemse/bjr017.
PMID
21502338.
External links
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SSRIsTooltip Selective serotonin reuptake inhibitors | |
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SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors | |
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NRIsTooltip Norepinephrine reuptake inhibitors | |
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NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors | |
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NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants | |
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SARIsTooltip Serotonin antagonist and reuptake inhibitors | |
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SMSTooltip Serotonin modulator and stimulators | |
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TCAsTooltip Tricyclic antidepressants | |
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TeCAsTooltip Tetracyclic antidepressants | |
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Others | |
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Non-selective | |
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MAOATooltip Monoamine oxidase A-selective | |
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MAOBTooltip Monoamine oxidase B-selective | |
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