From Wikipedia, the free encyclopedia
Protein-coding gene in humans
CDGSH iron sulfur domain 2 is a
protein that in humans is encoded by the CISD2
gene .
[5]
The protein encoded by this gene is a
zinc finger protein that localizes to the
endoplasmic reticulum . The encoded protein binds an
iron/sulfur cluster and may be involved in
calcium homeostasis . Defects in this gene are a cause of
Wolfram syndrome 2 . [provided by RefSeq, Mar 2011].
Shu SG, Tsai CR, Chi CS (November 2003). "Wolfram syndrome: phenotype and novel mutation in two Taiwanese siblings". J. Formos. Med. Assoc . 102 (11): 808–11.
PMID
14724730 .
Amr S, Heisey C, Zhang M, Xia XJ, Shows KH, Ajlouni K, Pandya A, Satin LS, El-Shanti H, Shiang R (October 2007).
"A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2" . Am. J. Hum. Genet . 81 (4): 673–83.
doi :
10.1086/520961 .
PMC
2227919 .
PMID
17846994 .
Conlan AR, Axelrod HL, Cohen AE, Abresch EC, Zuris J, Yee D, Nechushtai R, Jennings PA, Paddock ML (September 2009).
"Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2" . J. Mol. Biol . 392 (1): 143–53.
doi :
10.1016/j.jmb.2009.06.079 .
PMC
2739586 .
PMID
19580816 .
Chang NC, Nguyen M, Germain M, Shore GC (February 2010).
"Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1" . EMBO J . 29 (3): 606–18.
doi :
10.1038/emboj.2009.369 .
PMC
2830692 .
PMID
20010695 .
Chen YF, Wu CY, Kirby R, Kao CH, Tsai TF (July 2010). "A role for the CISD2 gene in lifespan control and human disease". Ann. N. Y. Acad. Sci . 1201 (1): 58–64.
Bibcode :
2010NYASA1201...58C .
doi :
10.1111/j.1749-6632.2010.05619.x .
PMID
20649540 .
S2CID
22176942 .
Tamir S, Zuris JA, Agranat L, Lipper CH, Conlan AR, Michaeli D, Harir Y, Paddock ML, Mittler R, Cabantchik ZI, Jennings PA, Nechushtai R (2013).
"Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs" . PLOS ONE . 8 (5): e61202.
Bibcode :
2013PLoSO...861202T .
doi :
10.1371/journal.pone.0061202 .
PMC
3661554 .
PMID
23717386 .
Sohn YS, Tamir S, Song L, Michaeli D, Matouk I, Conlan AR, Harir Y, Holt SH, Shulaev V, Paddock ML, Hochberg A, Cabanchick IZ, Onuchic JN, Jennings PA, Nechushtai R, Mittler R (September 2013).
"NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth" . Proc. Natl. Acad. Sci. U.S.A . 110 (36): 14676–81.
Bibcode :
2013PNAS..11014676S .
doi :
10.1073/pnas.1313198110 .
PMC
3767537 .
PMID
23959881 .
Tamir S, Rotem-Bamberger S, Katz C, Morcos F, Hailey KL, Zuris JA, Wang C, Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings PA, Friedler A, Nechushtai R (April 2014).
"Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1" . Proc. Natl. Acad. Sci. U.S.A . 111 (14): 5177–82.
Bibcode :
2014PNAS..111.5177T .
doi :
10.1073/pnas.1403770111 .
PMC
3986192 .
PMID
24706857 .
Liu L, Xia M, Wang J, Zhang W, Zhang Y, He M (September 2014). "CISD2 expression is a novel marker correlating with pelvic lymph node metastasis and prognosis in patients with early-stage cervical cancer". Med. Oncol . 31 (9): 183.
doi :
10.1007/s12032-014-0183-5 .
PMID
25134919 .
S2CID
40242445 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .