Crystallographic structure (PDB:
2QH7) of the CDGSH-type domain 1 dimer (green and cyan cartoon) complexed with iron (brown) and sulfur (yellow) Fe-S clusters.
The CDGSH iron sulfur domain are a group of
iron-sulfur (2Fe-2S) clusters and a unique 39 amino acid CDGSH domain [C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H].
The CDGSH iron sulfur domain 1 protein (also referred to as mitoNEET) is an
integral membrane protein located in the
outer mitochondrial membrane and whose function may be to transport iron into the mitochondria.[1] Iron in turn is essential for the function of several mitochondrial
enzymes.