Chymotrypsin-like elastase family member 1 (CELA1) also known as elastase-1 (ELA1) is an
enzyme that in humans is encoded by the CELA1
gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B.
Tissue distribution
Elastase-1 was formerly designated pancreatic elastase 1. However unlike other
elastases, pancreatic elastase 1 is not expressed in the pancreas. Hence this enzyme has been renamed as elastase-1. To date, elastase 1 expression has only been detected in skin
keratinocytes. Literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B
CELA3B).
Clinical significance
This enzyme has been linked to chronic pancreatitis .[5]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gullo L, Ventrucci M, Tomassetti P, Migliori M, Pezzilli R (January 1999). "Fecal elastase 1 determination in chronic pancreatitis". Digestive Diseases and Sciences. 44 (1): 210–3.
doi:
10.1023/A:1026691209094.
PMID9952246.
S2CID1137506.
Further reading
Gullo L, Ventrucci M, Tomassetti P, Migliori M, Pezzilli R (January 1999). "Fecal elastase 1 determination in chronic pancreatitis". Digestive Diseases and Sciences. 44 (1): 210–3.
doi:
10.1023/A:1026691209094.
PMID9952246.
S2CID1137506.
Borowitz D, Baker SS, Duffy L, Baker RD, Fitzpatrick L, Gyamfi J, Jarembek K (September 2004). "Use of fecal elastase-1 to classify pancreatic status in patients with cystic fibrosis". The Journal of Pediatrics. 145 (3): 322–6.
doi:
10.1016/j.jpeds.2004.04.049.
PMID15343184.
Gustavsson EL, Ohlsson K, Olsson AS (1980). "Interaction between human pancreatic elastase and plasma protease inhibitors". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 361 (2): 169–76.
doi:
10.1515/bchm2.1980.361.1.169.
PMID6153632.
Tani T, Kawashima I, Furukawa H, Ohmine T, Takiguchi Y (March 1987). "Characterization of a silent gene for human pancreatic elastase I: structure of the 5'-flanking region". Journal of Biochemistry. 101 (3): 591–9.
doi:
10.1093/jb/101.3.591.
PMID3648024.
Kawashima I, Tani T, Mita-Honjo K, Shimoda-Takano K, Ohmine T, Furukawa H, Takiguchi Y (1992). "Genomic organization of the human homologue of the rat pancreatic elastase I gene". DNA Sequence. 2 (5): 303–12.
doi:
10.3109/10425179209030963.
PMID1633328.
Tsunemi M, Matsuura Y, Sakakibara S, Katsube Y (September 1996). "Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution". Biochemistry. 35 (36): 11570–6.
doi:
10.1021/bi960900l.
PMID8794736.
External links
The
MEROPS online database for peptidases and their inhibitors:
S01.153