From Wikipedia, the free encyclopedia
Enzyme
Archaeosine synthase (
EC
2.6.1.97, ArcS, TgtA2, MJ1022 (gene), glutamine:preQ0-tRNA amidinotransferase) is an
enzyme with
systematic name L-glutamine:7-cyano-7-carbaguanine aminotransferase.
[1]
[2] This enzyme
catalyses the following
chemical reaction
- L-
glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O
L-
glutamate + archaeine15 in tRNA
In
Euryarchaeota the reaction is catalysed by ArcS.
References
-
^ Phillips G, Chikwana VM, Maxwell A, El-Yacoubi B, Swairjo MA, Iwata-Reuyl D, de Crécy-Lagard V (April 2010).
"Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA". The Journal of Biological Chemistry. 285 (17): 12706–13.
doi:
10.1074/jbc.M110.102236.
PMC
2857094.
PMID
20129918.
-
^ Phillips G, Swairjo MA, Gaston KW, Bailly M, Limbach PA, Iwata-Reuyl D, de Crécy-Lagard V (February 2012).
"Diversity of archaeosine synthesis in crenarchaeota". ACS Chemical Biology. 7 (2): 300–5.
doi:
10.1021/cb200361w.
PMC
3289047.
PMID
22032275.
External links
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