Australian-British embryologist
Andrew 'Andy' Charles Oates (born 1969 in
Adelaide ,
Australia ) is an
Australian and
British
developmental biologist and
embryologist specialized in biological
pattern formation . He is professor at
EPFL (École Polytechnique Fédérale de Lausanne) and head of the Segmentation Timing and Dynamics Laboratory at
EPFL 's School of Life Sciences.
[1]
[2]
[3] Since 2021, he has been dean of
EPFL 's School of Life Sciences.
[4]
Career
Oates received an undergraduate degree in
biochemistry with honors for his work at the Robert Saint's laboratory at the
University of Adelaide in 1992. He then joined Andrew F. Wilks at the
Ludwig Institute for Cancer Research and at the
University of Melbourne as PhD student, and graduated in 1998.
[5] His postdoctoral time was at the laboratory of Robert Ho both at
Princeton University and at
University of Chicago , where he began his studies on the segmentation clock in
zebrafish .
[6] In 2003, he moved to the
Max Planck Institute of Molecular Cell Biology and Genetics in Dresden to start his research group.
[7]
[8] In 2012, he became professor of vertebrate developmental genetics at
University College London and moved his group to the
National Institute for Medical Research at
Mill Hill in
London .
[9] In April 2015, he became a member of the
Francis Crick Institute in
London .
[10]
In 2016, he joined
EPFL as a full professor, where he is the founder and director of the Timing, Oscillation, Patterns Laboratory at
EPFL 's School of Life Sciences.
[1]
[2]
[3]
Since 2018, he has served as director of the
EPFL 's Institute of Bioengineering,
[11] and since January 2021 he has been the dean of the
EPFL 's School of Life Sciences.
[4]
Research
Oates' research laboratory is composed of
biologists ,
engineers , and
physicists . It draws on
molecular genetics , quantitative imaging, and theoretical analysis in order to investigate populations of coupled genetic oscillators in vertebrate
embryos , termed as segmentation clocks.
[12] These systems drive the rhythmic, sequential, and precise formation of embryonic body segments, exhibiting rich spatial and temporal phenomena spanning from molecular to tissue scales.
[13]
[14]
The laboratory' contributions are the direct connection of genes to segmentation rhythm, and the discovery that the rhythm also involves physical, collective processes at multi-cellular and tissue scales.
[15]
[16]
Distinctions
Oates is a member of the British Society of Developmental Biology.
[17] He is the recipient of the R.K. Mortenson Prize for Biochemistry 1991.
Selected works
Negrete, Jose; Oates, Andrew C. (2019).
"Embryonic lateral inhibition as optical modes: An analytical framework for mesoscopic pattern formation" . Physical Review E . 99 (4): 042417.
arXiv :
1808.09362 .
Bibcode :
2019PhRvE..99d2417N .
doi :
10.1103/PhysRevE.99.042417 .
PMID
31108612 .
S2CID
104644290 .
Lleras Forero, Laura; Narayanan, Rachna; Huitema, Leonie FA; Vanbergen, Maaike; Apschner, Alexander; Peterson-Maduro, Josi; Logister, Ive; Valentin, Guillaume; Morelli, Luis G.; Oates, Andrew C.; Schulte-Merker, Stefan (2018).
"Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock" . eLife . 7 .
doi :
10.7554/eLife.33843 .
PMC
5962341 .
PMID
29624170 .
Richter, Sandra; Schulze, Ulrike; Tomançak, Pavel; Oates, Andrew C. (2017).
"Small molecule screen in embryonic zebrafish using modular variations to target segmentation" . Nature Communications . 8 (1): 1901.
Bibcode :
2017NatCo...8.1901R .
doi :
10.1038/s41467-017-01469-5 .
PMC
5711842 .
PMID
29196645 .
Liao, Bo-Kai; Jörg, David J.; Oates, Andrew C. (2016).
"Faster embryonic segmentation through elevated Delta-Notch signalling" . Nature Communications . 7 : 11861.
Bibcode :
2016NatCo...711861L .
doi :
10.1038/ncomms11861 .
PMC
4912627 .
PMID
27302627 .
Webb, Alexis B.; Lengyel, Iván M.; Jörg, David J.; Valentin, Guillaume; Jülicher, Frank; Morelli, Luis G.; Oates, Andrew C. (2016).
"Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock" . eLife . 5 .
doi :
10.7554/eLife.08438 .
PMC
4803185 .
PMID
26880542 .
Soroldoni, D.; Jorg, D. J.; Morelli, L. G.; Richmond, D. L.; Schindelin, J.; Julicher, F.; Oates, A. C. (2014).
"A Doppler effect in embryonic pattern formation" . Science . 345 (6193): 222–225.
Bibcode :
2014Sci...345..222S .
doi :
10.1126/science.1253089 .
PMC
7611034 .
PMID
25013078 .
S2CID
206556621 .
Bajard, L.; Morelli, L. G.; Ares, S.; Pecreaux, J.; Julicher, F.; Oates, A. C. (2014).
"WNT-regulated dynamics of positional information in zebrafish somitogenesis" . Development . 141 (6): 1381–1391.
doi :
10.1242/dev.093435 .
PMC
3943186 .
PMID
24595291 .
Schröter, Christian; Ares, Saúl; Morelli, Luis G.; Isakova, Alina; Hens, Korneel; Soroldoni, Daniele; Gajewski, Martin; Jülicher, Frank; Maerkl, Sebastian J.; Deplancke, Bart; Oates, Andrew C. (2012).
"Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit" . PLOS Biology . 10 (7): e1001364.
doi :
10.1371/journal.pbio.1001364 .
PMC
3404119 .
PMID
22911291 .
References
^
a
b
"Brexit: closer cooperation with the UK cannot replace participation in Horizon 2020 | ETH-Board" . www.ethrat.ch . Archived from
the original on 9 January 2021. Retrieved 21 December 2020 .
^
a
b
"oateslab" . www.epfl.ch . Retrieved 21 December 2020 .
^
a
b
"Andrew Charles Oates" . people.epfl.ch . Retrieved 21 December 2020 .
^
a
b
"New deans for the Basic Sciences and Life Sciences" . 12 November 2020.
^ Nicholson, S. E.; Oates, A. C.; Harpur, A. G.; Ziemiecki, A.; Wilks, A. F.; Layton, J. E. (12 April 1994).
"Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation" . Proceedings of the National Academy of Sciences . 91 (8): 2985–2988.
Bibcode :
1994PNAS...91.2985N .
doi :
10.1073/pnas.91.8.2985 .
ISSN
0027-8424 .
PMC
43499 .
PMID
7512720 .
^ Oates, Andrew C; Bruce, Ashley E.E; Ho, Robert K (August 2000).
"Too Much Interference: Injection of Double-Stranded RNA Has Nonspecific Effects in the Zebrafish Embryo" . Developmental Biology . 224 (1): 20–28.
doi :
10.1006/dbio.2000.9761 .
PMID
10898958 .
^ Schröter, Christian; Herrgen, Leah; Cardona, Albert; Brouhard, Gary J.; Feldman, Benjamin; Oates, Andrew C. (March 2008).
"Dynamics of zebrafish somitogenesis" . Developmental Dynamics . 237 (3): 545–553.
doi :
10.1002/dvdy.21458 .
PMID
18265021 .
S2CID
7038940 .
^ Uriu, Koichiro; Ares, Saúl; Oates, Andrew C.; Morelli, Luis G. (21 March 2013).
"Dynamics of mobile coupled phase oscillators" . Physical Review E . 87 (3): 032911.
Bibcode :
2013PhRvE..87c2911U .
doi :
10.1103/PhysRevE.87.032911 .
hdl :
11336/2452 .
ISSN
1539-3755 .
^ Soroldoni, D.; Jorg, D. J.; Morelli, L. G.; Richmond, D. L.; Schindelin, J.; Julicher, F.; Oates, A. C. (11 July 2014).
"A Doppler effect in embryonic pattern formation" . Science . 345 (6193): 222–225.
Bibcode :
2014Sci...345..222S .
doi :
10.1126/science.1253089 .
ISSN
0036-8075 .
PMC
7611034 .
PMID
25013078 .
S2CID
206556621 .
^
"King's College London - Randall Seminar: Professor Andrew Oates" . www.kcl.ac.uk . Retrieved 21 December 2020 .
^ Sanctuary, Hillary (25 August 2020).
"Andrew Oates, a Passion for Cycles" .
^ Naganathan, Sundar R.; Oates, Andrew C. (October 2017).
"Mechanochemical coupling and developmental pattern formation" . Current Opinion in Systems Biology . 5 : 104–111.
doi :
10.1016/j.coisb.2017.09.007 .
^
"Research" . www.epfl.ch . Retrieved 21 December 2020 .
^ Lleras Forero, Laura; Narayanan, Rachna; Huitema, Leonie FA; VanBergen, Maaike; Apschner, Alexander; Peterson-Maduro, Josi; Logister, Ive; Valentin, Guillaume; Morelli, Luis G; Oates, Andrew C; Schulte-Merker, Stefan (6 April 2018). Whitfield, Tanya T. (ed.).
"Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock" . eLife . 7 : e33843.
doi :
10.7554/eLife.33843 .
ISSN
2050-084X .
PMC
5962341 .
PMID
29624170 .
S2CID
4605280 .
^ Oates, Andrew C (August 2020).
"Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks" . Current Opinion in Genetics & Development . 63 : 61–70.
doi :
10.1016/j.gde.2020.04.008 .
PMID
32505051 .
^ Venzin, Olivier F.; Oates, Andrew C. (April 2020).
"What are you synching about? Emerging complexity of Notch signaling in the segmentation clock" . Developmental Biology . 460 (1): 40–54.
doi :
10.1016/j.ydbio.2019.06.024 .
PMID
31302101 .
^
"Newsletter" (PDF) . British Society for Developmental Biology .
External links
International National Academics Other