From Wikipedia, the free encyclopedia
In
enzymology , an aminobutyraldehyde dehydrogenase (
EC
1.2.1.19 ) is an
enzyme that
catalyzes the
chemical reaction
4-aminobutanal + NAD+ + H2 O
⇌
{\displaystyle \rightleftharpoons }
4-aminobutanoate + NADH + 2 H+
The 3
substrates of this enzyme are
4-aminobutanal ,
NAD+ , and
H2 O , whereas its 3
products are
4-aminobutanoate ,
NADH , and
H+ .
This enzyme belongs to the family of
oxidoreductases , specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The
systematic name of this enzyme class is 4-aminobutanal:NAD+ 1-oxidoreductase . Other names in common use include gamma-guanidinobutyraldehyde dehydrogenase (ambiguous) , ABAL dehydrogenase , 4-aminobutyraldehyde dehydrogenase , 4-aminobutanal dehydrogenase , gamma-aminobutyraldehyde dehydrogenase , 1-pyrroline dehydrogenase , ABALDH , and YdcW . This enzyme participates in the
urea cycle and the metabolism of
amino groups and
beta-alanine .
References
Callewaert, Denis M.; Rosemblatt, Mario S.; Tchen, T. T. (1974-03-25).
"Purification and Properties of 4-Aminobutanal Dehydrogenase from a Pseudomonas Species" . Journal of Biological Chemistry . 249 (6): 1737–1741.
ISSN
0021-9258 .
PMID
4817964 . Retrieved 2019-04-08 .
Boyer, P.D.; Lardy, H.; Myrback, K., eds. (1963). The Enzymes . Vol. 7 (2nd ed.). New York: Academic Press. pp. 203–221.
Jakoby, William B.; Fredericks, Joan (1959-08-01).
"Pyrrolidine and Putrescine Metabolism: γ-Aminobutyraldehyde Dehydrogenase" . Journal of Biological Chemistry . 234 (8): 2145–2150.
ISSN
0021-9258 .
PMID
13673029 . Retrieved 2019-04-08 .
Matsuda H, Suzuki Y (1984).
"gamma-Guanidinobutyraldehyde Dehydrogenase of Vicia faba Leaves" . Plant Physiol . 76 (3): 654–657.
doi :
10.1104/pp.76.3.654 .
PMC
1064350 .
PMID
16663901 .
Yorifuji T, Koike K, Sakurai T, Yokoyama K (1986).
"4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida" . Agric. Biol. Chem . 50 (8): 2009–2016.
doi :
10.1271/bbb1961.50.2009 .
A; Martín-Checa, J; Balaña-Fouce, R; Garrido-Pertierra, A (1986). "A pathway for putrescine catabolism in Escherichia coli". Biochim. Biophys. Acta . 880 (2–3): 242–4.
doi :
10.1016/0304-4165(86)90085-1 .
PMID
3510672 .
Prieto MI, Martin J, Balana-Fouce R, Garrido-Pertierra A (1987). "Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli". Biochimie . 69 (11–12): 1161–8.
doi :
10.1016/0300-9084(87)90142-8 .
PMID
3129020 .
Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR (2005).
"Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase" . FEBS Lett . 579 (19): 4107–12.
doi :
10.1016/j.febslet.2005.06.038 .
PMID
16023116 .
Activity Regulation Classification Kinetics Types