From Wikipedia, the free encyclopedia
Class of enzymes
All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) (
EC
2.5.1.85 , nonaprenyl diphosphate synthase , solanesyl diphosphate synthase , At-SPS2 , At-SPS1 , SPS1 , SPS2 ) is an
enzyme with
systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units) .
[1]
[2]
[3] This enzyme
catalyses the following
chemical reaction
geranylgeranyl diphosphate + 5
isopentenyl diphosphate
⇌
{\displaystyle \rightleftharpoons }
5
diphosphate + all-trans-nonaprenyl diphosphate
Geranylgeranyl diphosphate is preferred over
farnesyl diphosphate as
allylic substrate.
In 2020,
aclonifen was shown to inhibit the enzyme and is the first compound to have this
mechanism of action as a herbicide.
[4]
References
^ Hirooka K, Bamba T, Fukusaki E, Kobayashi A (March 2003).
"Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase" . The Biochemical Journal . 370 (Pt 2): 679–86.
doi :
10.1042/BJ20021311 .
PMC
1223189 .
PMID
12437513 .
^ Hirooka K, Izumi Y, An CI, Nakazawa Y, Fukusaki E, Kobayashi A (March 2005).
"Functional analysis of two solanesyl diphosphate synthases from Arabidopsis thaliana" . Bioscience, Biotechnology, and Biochemistry . 69 (3): 592–601.
doi :
10.1271/bbb.69.592 .
PMID
15784989 .
^ Jun L, Saiki R, Tatsumi K, Nakagawa T, Kawamukai M (December 2004).
"Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana" . Plant & Cell Physiology . 45 (12): 1882–8.
doi :
10.1093/pcp/pch211 .
PMID
15653808 .
^ Kahlau, Sabine; Schröder, Florian; Freigang, Jörg; Laber, Bernd; Lange, Gudrun; Passon, Daniel; Kleeßen, Sabrina; Lohse, Marc; Schulz, Arno; von Koskull‐Döring, Pascal; Klie, Sebastian; Gille, Sascha (October 2020). "Aclonifen targets solanesyl diphosphate synthase, representing a novel mode of action for herbicides". Pest Management Science . 76 (10): 3377–3388.
doi :
10.1002/ps.5781 .
External links
Activity Regulation Classification Kinetics Types