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Class of enzymes
Abieta-7,13-dien-18-ol hydroxylase (
EC
1.14.13.109 , CYP720B1 , PTAO ) is an
enzyme with
systematic name abieta-7,13-dien-18-ol,NADPH:oxygen oxidoreductase (18-hydroxylating) .
[1]
[2]
[3] This enzyme
catalyses the following
chemical reaction
abieta-7,13-dien-18-ol + NADPH + H+ + O2
⇌
{\displaystyle \rightleftharpoons }
abieta-7,13-dien-18-al + NADP+ + 2 H2 O (overall reaction)
(1a) abieta-7,13-dien-18-ol + NADPH + H+ + O2
⇌
{\displaystyle \rightleftharpoons }
abieta-7,13-dien-18,18-diol + + NADP+ + H2 O:
(1b) abieta-7,13-dien-18,18-diol
⇌
{\displaystyle \rightleftharpoons }
abieta-7,13-dien-18-al + H2 O (spontaneous)
Abietadienol hydroxylase is a heme-thiolate protein (P-450).
References
^ Funk C, Croteau R (January 1994). "Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis". Archives of Biochemistry and Biophysics . 308 (1): 258–66.
doi :
10.1006/abbi.1994.1036 .
PMID
8311462 .
^ Funk C, Lewinsohn E, Vogel BS, Steele CL, Croteau R (November 1994).
"Regulation of Oleoresinosis in Grand Fir (Abies grandis) (Coordinate Induction of Monoterpene and Diterpene Cyclases and Two Cytochrome P450-Dependent Diterpenoid Hydroxylases by Stem Wounding)" . Plant Physiology . 106 (3): 999–1005.
doi :
10.1104/pp.106.3.999 .
PMC
159624 .
PMID
12232380 .
^ Ro DK, Arimura G, Lau SY, Piers E, Bohlmann J (May 2005).
"Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase" . Proceedings of the National Academy of Sciences of the United States of America . 102 (22): 8060–5.
Bibcode :
2005PNAS..102.8060R .
doi :
10.1073/pnas.0500825102 .
PMC
1138258 .
PMID
15911762 .
External links
CYP1 CYP2 CYP3 (
CYP3A ) CYP4 CYP5-20 CYP21-49 CYP51-69 CYP71-99
CYP71 (
C1 ,
C2 ,
C3 ,
C4 ,
Z6 ,
AJ4 ,
AV1 ,
BA1 )
CYP72A1
CYP73A1
CYP74 (
D1 )
CYP75 (
A1 ,
B1 )
CYP76 (
B6 ,
M7 )
CYP79 (
A1 ,
A2 ,
B1 ,
B2 ,
B3 ,
D1 ,
D2 ,
D3 ,
D4 )
CYP80 (
A1 ,
B1 ,
G2 )
CYP81 (
E1 ,
E3 ,
E7 ,
E9 )
CYP88D6
CYP90C1
CYP93E1
CYP97C1
CYP99A3
CYP101-281 CYP301-499 CYP501-699 CYP701-999