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6-hydroxypseudooxynicotine dehydrogenase)
| 6-hydroxypseudooxynicotine dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.99.14 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
6-hydroxypseudooxynicotine dehydrogenase ( EC 1.5.99.14) is an enzyme with systematic name 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one:acceptor 6-oxidoreductase (hydroxylating). [1] [2] [3] This enzyme catalyses the following chemical reaction:
- 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + acceptor + H2O 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced acceptor
This enzyme contains a cytidylyl molybdenum cofactor.
References
- ^ Freudenberg W, Konig K, Andreesen JR (1988). "Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase". FEMS Microbiology Letters. 52: 13–18. doi: 10.1111/j.1574-6968.1988.tb02564.x.
- ^ Grether-Beck S, Igloi GL, Pust S, Schilz E, Decker K, Brandsch R (September 1994). "Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans". Molecular Microbiology. 13 (5): 929–36. doi: 10.1111/j.1365-2958.1994.tb00484.x. PMID 7815950.
- ^ Sachelaru P, Schiltz E, Brandsch R (July 2006). "A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans". Applied and Environmental Microbiology. 72 (7): 5126–31. doi: 10.1128/AEM.00437-06. PMC 1489357. PMID 16820521.
External links
- 6-hydroxypseudooxynicotine+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
