GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D- glucosaminyl-R
Thus, the two
substrates of this enzyme are
GDP-beta-L-fucose and [[beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R]], whereas its 3
products are
GDP, [[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-]], and
glucosaminyl-R.
This enzyme belongs to the family of
glycosyltransferases, specifically the hexosyltransferases. The
systematic name of this enzyme class is GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase. Other names in common use include:
GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R, and 4I-alpha-L-fucosyltransferase.
References
Prieels JP, Monnom D, Dolmans M, Beyer TA, Hill RL (October 1981). "Co-purification of the Lewis blood group N-acetylglucosaminide alpha 1 goes to 4 fucosyltransferase and an N-acetylglucosaminide alpha 1 goes to 3 fucosyltransferase from human milk". The Journal of Biological Chemistry. 256 (20): 10456–63.
PMID7287719.