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Class of enzymes
2-hydroxyethylphosphonate dioxygenase (
EC
1.13.11.72, HEPD, phpD (gene)) is an
enzyme with
systematic name 2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (hydroxymethylphosphonate forming).
[1]
[2]
[3] This enzyme
catalyses the following
chemical reaction
- 2-hydroxyethylphosphonate + O2
hydroxymethylphosphonate +
formate
2-hydroxyethylphosphonate dioxygenase contains non-heme-Fe(II).
References
-
^ Cicchillo RM, Zhang H, Blodgett JA, Whitteck JT, Li G, Nair SK, van der Donk WA, Metcalf WW (June 2009).
"An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis". Nature. 459 (7248): 871–4.
doi:
10.1038/nature07972.
PMC
2874955.
PMID
19516340.
-
^ Whitteck JT, Malova P, Peck SC, Cicchillo RM, Hammerschmidt F, van der Donk WA (March 2011).
"On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase". Journal of the American Chemical Society. 133 (12): 4236–9.
doi:
10.1021/ja1113326.
PMC
3069692.
PMID
21381767.
-
^ Peck SC, Cooke HA, Cicchillo RM, Malova P, Hammerschmidt F, Nair SK, van der Donk WA (August 2011).
"Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase". Biochemistry. 50 (30): 6598–605.
doi:
10.1021/bi200804r.
PMC
3143709.
PMID
21711001.
External links
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