This enzyme belongs to the family of
transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The
systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase. Other names in common use include heparin-glucosamine 3-O-sulfotransferase, 3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase, glucosaminyl 3-O-sulfotransferase, heparan sulfate D-glucosaminyl 3-O-sulfotransferase, and isoform/isozyme 1 (3-OST-1, HS3ST1). This enzyme participates in
heparan sulfate biosynthesis and
glycan structures - biosynthesis 1.
Structural studies
As of late 2007, two
structures have been solved for this class of enzymes, with
PDB accession codes
1VKJ and
1ZRH.
References
Kusche M, Backstrom G, Riesenfeld J, Petitou M, Choay J, Lindahl U (1988). "Biosynthesis of heparin. O-sulfation of the antithrombin-binding region". J. Biol. Chem. 263 (30): 15474–84.
PMID3139669.