Names | |
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Preferred IUPAC name
(1S)-1-Hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-5(1H)-one | |
Identifiers | |
3D model (
JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.208.620 |
PubChem
CID
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UNII | |
CompTox Dashboard (
EPA)
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Properties | |
C11H10N2O2 | |
Molar mass | 202.213 g·mol−1 |
Density | 1.5 g/cm3 |
Melting point | 200 to 202 °C (392 to 396 °F; 473 to 475 K) |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Vasicinone is a quinazoline alkaloid. It shows bronchodilator action in vitro [1] but bronchoconstrictor action in vivo. [2] Vasicinone was shown to have an antianaphylactic action. [3] It has been found within Peganum harmala. [4]
Vasicinone has also been studied in combination with the related alkaloid vasicine. Both the alkaloids in combination (1:1) showed pronounced bronchodilatory activity in vivo and in vitro. [5] Both alkaloids are also respiratory stimulants. [5] Vasicine has a cardiac–depressant effect, while vasicinone is a weak cardiac stimulant; the effect can be normalized by combining the alkaloids. [5] [3] Vasicine is reported to have a uterine stimulant effect. [3]