From Wikipedia, the free encyclopedia
Delivery of a substance inside the vagina
Administering medication vaginally using an applicator.
Administering medication vaginally without an applicator.
Intravaginal administration is a
route of administration where the substance is applied inside the
vagina .
Pharmacologically , it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the
vaginal portion of cervix ) with limited systemic
adverse effects compared to other routes of administration.
[1]
[2]
[3]
Formulation methods include vaginal
tablets , vaginal
cream , vaginal gel,
[4] vaginal
suppository and
vaginal ring .
Medicines primarily delivered by intravaginal administration include
vaginally administered estrogens and
progestogens (a group of hormones including
progesterone ), and
antibacterials and
antifungals to treat
bacterial vaginosis and
yeast infections respectively.
Medicines may also be administered intravaginally as an alternative to
oral route in the case of
nausea or other digestive problems.
[5]
It is a potential means of
artificial insemination (referred to as intravaginal insemination or IVI), sometimes used at home without the presence of a professional.
[6]
It is used as an administration method for contraception.
[4]
References
^ Alexander, Nancy J.; Baker, Edward; Kaptein, Marc; Karck, Ulrich; Miller, Leslie; Zampaglione, Edio (2004-07-01).
"Why consider vaginal drug administration?" . Fertility and Sterility . 82 (1): 1–12.
doi :
10.1016/j.fertnstert.2004.01.025 .
ISSN
0015-0282 .
PMID
15236978 .
^ Hussain, Alamdar; Ahsan, Fakhrul (2005-03-21). "The vagina as a route for systemic drug delivery". Journal of Controlled Release . 103 (2): 301–313.
doi :
10.1016/j.jconrel.2004.11.034 .
ISSN
0168-3659 .
PMID
15763615 .
^ Doyle, Glynda Rees; McCutcheon, Jodie Anita (23 November 2015).
"6.4 Administering Medications Rectally and Vaginally | Clinical Procedures for Safer Patient Care" . opentextbc.ca . Retrieved 2017-05-02 .
^
a
b
"U.S. FDA Approves Evofem Biosciences' Phexxi (lactic acid, citric acid and potassium bitartrate), the First and Only Non-Hormonal Prescription Gel for the Prevention of Pregnancy" . Evofem Biosciences (Press release). 22 May 2020. Retrieved 22 May 2020 – via PR Newswire.
^ Woolfson, A. David; Malcolm, R. Karl; Gallagher, Rory (2000-01-01). "Drug Delivery by the Intravaginal Route". Critical Reviews in Therapeutic Drug Carrier Systems . 17 (5): 509–555.
doi :
10.1615/CritRevTherDrugCarrierSyst.v17.i5.30 .
ISSN
0743-4863 .
PMID
11108158 .
^
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