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Clinical data | |
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Trade names | Synthroid, Levoxyl, Thyrax, others |
Other names | 3,5,3′,5′-Tetraiodo-L-thyronine |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a682461 |
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Pregnancy category |
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Routes of administration | By mouth, intravenous |
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Pharmacokinetic data | |
Bioavailability | 40-80% [2] |
Metabolism | mainly in liver, kidneys, brain and muscles |
Elimination half-life | ca. 7 days (in hyperthyroidism 3–4 days, in hypothyroidism 9–10 days) |
Excretion | feces and urine |
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Chemical and physical data | |
Formula | C15H11I4NO4 |
Molar mass | 776.874 g·mol−1 |
3D model ( JSmol) | |
Melting point | 231 to 233 °C (448 to 451 °F) [3] |
Solubility in water | Slightly soluble (0.105 mg·mL−1 at 25 °C) [4] mg/mL (20 °C) |
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Levothyroxine, also known as L-thyroxine, is a manufactured form of the thyroid hormone thyroxine (T4). [2] [6] It is used to treat thyroid hormone deficiency, including the severe form known as myxedema coma. [2] It may also be used to treat and prevent certain types of thyroid tumors. [2] It is not indicated for weight loss. [2] Levothyroxine is taken by mouth or given by injection into a vein. [2] Maximum effect from a specific dose can take up to six weeks to occur. [2]
Side effects from excessive doses include weight loss, trouble tolerating heat, sweating, anxiety, trouble sleeping, tremor, and fast heart rate. [2] Use is not recommended in people who have had a recent heart attack. [2] Use during pregnancy has been found to be safe. [2] It is recommended that dosing be based on regular measurements of thyroid-stimulating hormone (TSH) and T4 levels in the blood. [2] Much of the effect of levothyroxine is following its conversion to triiodothyronine (T3). [2]
Levothyroxine was first made in 1927. [6] It is on the World Health Organization's List of Essential Medicines. [7] Levothyroxine is available as a generic medication. [2] The wholesale cost in the developing world is about US$0.58 to US$12.28 per month. [8] In the United States, a typical month of treatment costs less than US$25. [9] Levothyroxine was the third most commonly prescribed medication in the United States in 2017, with more than 101 million prescriptions. [10] [11]