Serious Business may refer to

• Serious Business (Johnny Winter album), 1985
• Serious Business (Third World album), 1989
• "Serious Business", a song from the album Uh-huh by John Cougar Mellencamp and the B-side of "Pink Houses"
• Serious Business, one of the earliest game developers on Facebook, acquired by Zynga in 2010
• Serious Business Records, a record label founded by Travis Harrison and Andy Ross

• SIRIUS Business, a commercial background music service of Applied Media Technologies Corporation

This disambiguation page lists articles associated with the title Serious Business.
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