Ultraviolet–visible spectroscopy (UV–vis) can distinguish between
enantiomers by showing a distinct
Cotton effect for each isomer. UV–vis spectroscopy sees only
chromophores, so other molecules must be prepared for analysis by chemical addition of a chromophore such as
anthracene. Two methods are reported: the octant rule and the exciton chirality method.
[1]
^Structure and the Optical Rotatory Dispersion of Saturated Ketones William Moffitt, R. B. Woodward, A. Moscowitz, W. Klyne, Carl Djerassi J. Am. Chem. Soc., 1961, 83 (19), pp 4013–4018
doi:
10.1021/ja01480a015
^The octant rule: Its place in organic stereochemistry William S. Murphy J. Chem. Educ., 1975, 52 (12), p 774
doi:
10.1021/ed052p774
Publication Date: December 1975
^A Simple Computer-Aided Three-Dimensional Molecular Modeling for the Octant Rule Yinan Kang , Fu-An Kang J. Chem. Educ., 2011, 88 (4), p 420
doi:
10.1021/ed1001027