From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Netrin receptor UNC5A is a
protein that in humans is encoded by the UNC5A
gene .
[5]
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM]
[5]
Interactions
UNC5A has been shown to
interact with
MAGED1 .
[6]
References
Further reading
Arakawa H (December 2004). "Netrin-1 and its receptors in tumorigenesis". Nature Reviews. Cancer . 4 (12): 978–87.
doi :
10.1038/nrc1504 .
PMID
15573119 .
S2CID
867903 .
Bonaldo MF, Lennon G, Soares MB (September 1996).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research . 8 (6): 319–27.
doi :
10.1093/dnares/8.6.319 .
PMID
11853319 .
Williams ME, Strickland P, Watanabe K, Hinck L (May 2003).
"UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE" . The Journal of Biological Chemistry . 278 (19): 17483–90.
doi :
10.1074/jbc.M300415200 .
PMID
12598531 .
Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (March 2003). "p53RDL1 regulates p53-dependent apoptosis". Nature Cell Biology . 5 (3): 216–23.
doi :
10.1038/ncb943 .
PMID
12598906 .
S2CID
7017409 .
Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, et al. (April 2003).
"The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment" . Proceedings of the National Academy of Sciences of the United States of America . 100 (7): 4173–8.
Bibcode :
2003PNAS..100.4173T .
doi :
10.1073/pnas.0738063100 .
PMC
153067 .
PMID
12655055 .
Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ (August 2003).
"Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin" . The Journal of Biological Chemistry . 278 (35): 32561–8.
doi :
10.1074/jbc.M302943200 .
PMID
12810718 .
Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, et al. (March 2005).
"The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase" . The EMBO Journal . 24 (6): 1192–201.
doi :
10.1038/sj.emboj.7600584 .
PMC
556396 .
PMID
15729359 .