Ubiquitin-like modifier-activating enzyme 7 is a
protein that in humans is encoded by the UBA7gene.[5][6]
The modification of proteins with
ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
Ubiquitination involves at least three classes of
enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and
ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a
retinoid target that triggers
promyelocytic leukemia (PML)/
retinoic acid receptor alpha (RARalpha) degradation and
apoptosis in acute promyelocytic leukemia.[6]
Carritt B, Kok K, van den Berg A, et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer". Cancer Res. 52 (6): 1536–41.
PMID1311632.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9.
doi:
10.1038/nbt810.
PMID12665801.
S2CID23783563.
Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem. 138 (6): 711–9.
doi:
10.1093/jb/mvi172.
PMID16428300.