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Chemical compound
Troriluzole
Other names Trigriluzole, BHV-4157, FC-4157
Routes of administration
By mouth
2-amino-N-[2-[methyl-[2-oxo-2-[[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]amino]ethyl]amino]-2-oxoethyl]acetamide
CAS Number
PubChem
CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Formula C 15 H 16 F 3 N 5 O 4 S
Molar mass 419.38 g·mol−1 3D model (
JSmol )
CN(CC(=O)NC1=NC2=C(S1)C=C(C=C2)OC(F)(F)F)C(=O)CNC(=O)CN
InChI=1S/C15H16F3N5O4S/c1-23(13(26)6-20-11(24)5-19)7-12(25)22-14-21-9-3-2-8(4-10(9)28-14)27-15(16,17)18/h2-4H,5-7,19H2,1H3,(H,20,24)(H,21,22,25)
Key:YBZSGIWIPOUSHY-UHFFFAOYSA-N
Troriluzole (trigriluzole) is an experimental medication that has been investigated as a potential treatment for
spinocerebellar ataxia type 3 (SCA3),
[1]
[2]
[3]
[4]
obsessive-compulsive disorder ,
[3]
[4] and
glioblastoma .
[5] It is a prodrug formulation of the medication
riluzole .
[3]
[5]
Pharmacology
Pharmacokinetics
While riluzole is typically taken twice-daily and on an empty stomach, troriluzole may offer a potential once-daily dosing with or without food along with greater
bioavailability .
[3]
[5]
References
^ Meglio, Marco (25 June 2023).
"Biohaven Submits New Drug Application for Troriluzole as Spinocerebellar Ataxia Type 3 Therapy" . NeurologyLive . Retrieved 17 February 2024 .
^ Waldron, James (27 July 2023).
"Further blow for Biohaven as FDA refuses to consider failed rare disease drug for approval" . Fierce Biotech . Retrieved 17 February 2024 .
^
a
b
c
d Grassi G, Cecchelli C, Vignozzi L, Pacini S (2020).
"Investigational and Experimental Drugs to Treat Obsessive-Compulsive Disorder" .
Journal of Experimental Pharmacology . 12 : 695–706.
doi :
10.2147/JEP.S255375 .
PMC
7801912 .
PMID
33447096 .
^
a
b van Roessel PJ, Grassi G, Aboujaoude EN, Menchón JM, Van Ameringen M, Rodríguez CI (January 2023). "Treatment-resistant OCD: Pharmacotherapies in adults". Comprehensive Psychiatry . 120 : 152352.
doi :
10.1016/j.comppsych.2022.152352 .
hdl :
2445/192315 .
PMID
36368186 .
^
a
b
c Silk AW, Saraiya B, Groisberg R, Chan N, Spencer K, Girda E, Shih W, Palmeri M, Saunders T, Berman RM, Coric V, Chen S, Zloza A, Vieth J, Mehnert JM, Malhotra J (July 2022).
"A phase Ib dose-escalation study of troriluzole (BHV-4157), an oral glutamatergic signaling modulator, in combination with nivolumab in patients with advanced solid tumors" . European Journal of Medical Research . 27 (1): 107.
doi :
10.1186/s40001-022-00732-w .
PMC
9250196 .
PMID
35780243 .